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Synthesis of 14-deoxy-11,12-didehydroandrographolide Analogues as Potential Cytotoxic Agents for Cholangiocarcinoma

Sudarat Sombut, Rada Bunthawong, Uthaiwan Sirion, Teerapich Kasemsuk, Pawinee Piyachaturawat, Kanoknetr Suksen, Apichart Suksamrarn, Rungnapha Saeeng

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5139-5143.

PMID: 29097170

Abstract:

A series of 14-deoxy-11,12-didehydroandrographolide analogues were synthesized from naturally occurring andrographolide and their cytotoxicity evaluated against nine cancer cell lines including cholangiocarcinoma. Analogues 5a and 5b exhibited the most potent cytotoxicity with ED50s of 3.37 and 3.08 μM on KKU-M213 cell lines and 2.93 and 3.27 μM on KKU-100 cell lines, respectively. Selective cytotoxicity on cholangiocarcinoma cell lines identified in this study highlight the importance of structural modification in the development of drugs for this cancer.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP42895589 14-Deoxy-11,12-didehydroandrographolide 14-Deoxy-11,12-didehydroandrographolide 42895-58-9 Price
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