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Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an Inhibitor of Protein Sumoylation

Synthesis of 2',3',4'-trihydroxyflavone (2-D08), an Inhibitor of Protein Sumoylation

Yeong Sang Kim, Samantha G L Keyser, John S Schneekloth Jr

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1094-7.

PMID: 24468414

Abstract:

Protein sumoylation is a dynamic posttranslational modification involved in diverse biological processes during cellular homeostasis and development. Recently sumoylation has been shown to play a critical role in cancer, although to date there are few small molecule probes available to inhibit enzymes involved in the SUMO conjugation process. As part of a program to identify and study inhibitors of sumoylation we recently reported the discovery that 2',3',4'-trihydroxyflavone (2-D08) is a cell permeable, mechanistically unique inhibitor of protein sumoylation. The work reported herein describes an efficient synthesis of 2-D08 as well as a structurally related but inactive isomer. We also report an unanticipated Wessely-Moser rearrangement that occurs under vigorous methyl ether deprotection conditions. This rearrangement likely gave rise to 2-D08 during a deprotection step, resulting in 2-D08 appearing as a contaminant in a screening well from a commercial supplier.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP144707186	2-D08		144707-18-6	Price

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