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Synthesis of Bis(indolyl)methanes Using Hyper-Cross-Linked Polyaromatic Spheres Decorated With Bromomethyl Groups as Efficient and Recyclable Catalysts

Synthesis of Bis(indolyl)methanes Using Hyper-Cross-Linked Polyaromatic Spheres Decorated With Bromomethyl Groups as Efficient and Recyclable Catalysts

Reddi Mohan Naidu Kalla, Sung Chul Hong, Il Kim

ACS Omega. 2018 Feb 26;3(2):2242-2253.

PMID: 31458526

Abstract:

Highly uniform and hyper-cross-linked polyphenanthrene and polypyrene microspheres were synthesized by Friedel-Crafts bromomethylation of phenanthrene (Phn) and pyrene (Py) in the presence of zinc bromide as a catalyst, followed by self-polymerization of bromomethylated Phn and Py. The resultant 3-D carbon microspheres consisting of micro-, meso-, and macropores bear peripheral unreacted bromomethyl groups, which are directly utilized as catalysts to efficiently promote the electrophilic substitution reaction of indoles with aldehydes to yield a variety of bis(indolyl)methanes. The important features of this catalysis are easy catalyst synthesis, high product yields, environmental benignity, short reaction time, broad substrate scope, use of nontoxic solvents, and recyclability.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7699458	Zinc bromide		7699-45-8	Price

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