CAS 7699-45-8 Zinc bromide - Analytical Products / Alfa Chemistry

CAT	AP7699458
CAS	7699-45-8
Structure
MDL Number	MFCD00011294
Molecular Weight	225.20
EC Number	231-718-4
InChI Key	VNDYJBBGRKZCSX-UHFFFAOYSA-L

Linear Formula

ZnBr2

2-chlorophenyl Zinc Bromide: A Convenient Nucleophile for the Mannich-Related Multicomponent Synthesis of Clopidogrel and Ticlopidine

Isabelle Aillaud, Caroline Haurena, Erwan Le Gall, Thierry Martens, Gino Ricci

Molecules. 2010 Nov 11;15(11):8144-55.

PMID: 21072025

Dibromido(2,9-dimethyl-1,10-phenanthroline-κ(2)N,N')zinc

Ali Dehghani, Mostafa M Amini, Ezzatollah Najafi, Azadeh Tadjarodi, Behrouz Notash

Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):m811.

PMID: 22719356

Passerini Reactions on Biocatalytically Derived Chiral Azetidines

Lisa Moni, Luca Banfi, Andrea Basso, Andrea Bozzano, Martina Spallarossa, Ludger Wessjohann, Renata Riva

Molecules. 2016 Aug 30;21(9):1153.

PMID: 27589709

Practical Tetrafluoroethylene Fragment Installation Through a Coupling Reaction of (1,1,2,2-tetrafluorobut-3-en-1-yl)zinc Bromide With Various Electrophiles

Ken Tamamoto, Shigeyuki Yamada, Tsutomu Konno

Beilstein J Org Chem. 2018 Sep 11;14:2375-2383.

PMID: 30254702

Synthesis of Bis(indolyl)methanes Using Hyper-Cross-Linked Polyaromatic Spheres Decorated With Bromomethyl Groups as Efficient and Recyclable Catalysts

Reddi Mohan Naidu Kalla, Sung Chul Hong, Il Kim

ACS Omega. 2018 Feb 26;3(2):2242-2253.

PMID: 31458526

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Case Study

Preparation of Zinc Bromide Supported on Silica

Keivanloo, Ali, et al. Tetrahedron letters 52.13 (2011): 1498-1502.

Zinc bromide supported on silica (ZnBr₂/SiO₂) is an efficient heterogeneous catalyst that enables the rapid synthesis of alkynones through the cross-coupling of acyl chlorides with terminal alkynes under solvent-free conditions at room temperature, achieving excellent yields.
Preparation of ZnBr₂/SiO₂: Add silica gel (3.65 g) to a MeOH (20 mL) solution of ZnBr₂ (6 mmol, 1.35 g), and heat the mixture under reflux for 1 hour. Remove the solvent using a rotary evaporator and vacuum-dry the product at 150 °C for 10 hours. Inductively coupled plasma atomic absorption spectrometry (ICP) indicates that 1.2 mmol of ZnBr₂ is supported on 1 g of ZnBr₂/SiO₂.

Zinc Bromide for the Synthesis of Zinc Adenine/Adenine Complexes

Feda'a, M., et al. Inorganica Chimica Acta 557 (2023): 121716.

A new sustainable zinc adenine bromide (Zn-AHBr) catalyst is reported for catalyzing various epoxides using atmospheric CO₂ in the absence of additional catalysts.
Synthesis of Zinc Adenine/Adenine Complexes: Under a nitrogen atmosphere, 14.8 mmol of adenine (A) powder was suspended in 5 mL of deionized water using a 50 mL round-bottom flask to synthesize adenine bromide (AHBr). A stoichiometric amount of a 33% HBr/acetic acid solution was then added dropwise to the cooled suspension while maintaining the temperature below 5 °C. The transparent solution was left in the refrigerator overnight, resulting in a crystallization yield of 90%. The preparation method for the zinc bromide adenine (Zn-AHBr) complex involved dissolving 4.65 mmol of AHBr in a small amount of DMSO, then adding an equivalent amount of anhydrous ZnBr₂, and heating the solution to 80 °C for 1 hour. The solution was then cooled to room temperature (RT) and 5 mL of CHCl₃ was added. The product was separated using Et₂O, yielding an 80% yield.

Zinc Bromide (II) (ZnBr₂) as a Catalyst for the Synthesis of Heterocyclic Frameworks

Ghobadi, Massoud, Peiman Pourmoghaddam Qhazvini, and Mosstafa Kazemi. Synthetic Communications 50.24 (2020): 3717-3738.

The chemical properties of heterocyclic molecules are particularly significant in medicinal chemistry due to their critical importance to life. Compounds with pyrazole ring systems exhibit numerous pharmacological properties and can play vital roles in biochemical processes.
Under microwave irradiation at 60 °C in water, a library of 3-methyl-1-phenyl-1H-pyrazole-5(4H)-one derivatives with medicinal value was synthesized through the three-component condensation of various substituted aldehydes, ethyl acetoacetate, and phenylhydrazine/2,4-dinitrophenylhydrazine. Several metal salts were used to catalyze the template reaction of indole-3-aldehyde, phenylhydrazine, and ethyl acetoacetate in different reaction media to optimize the reaction conditions for synthesizing pyrazole products. After 24 hours, the yield of the template product was 46% without a catalyst. Under microwave irradiation at 60 °C in water, the maximum yield (98%) was achieved using SiO₂/ZnBr₂.