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Synthesis of the Sialidase Inhibitor Siastatin B

S Knapp, D Zhao

Org Lett. 2000 Dec 14;2(25):4037-40.

PMID: 11112637

Abstract:

[structure] The resolved piperidinecarboxylate (R)-7 was converted to siastatin B (1) by an efficient and stereoselective sequence that includes a bromo-beta-lactonization and an N-acyliminium azidation. Two analogues (3 and 4) of siastatin were also prepared.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP54795583 Siastatin B Siastatin B 54795-58-3 Price
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