0

Synthesis of Water-Soluble Prodrugs of BMS-191011: A maxi-K Channel Opener Targeted for Post-Stroke Neuroprotection

Piyasena Hewawasam, Min Ding, Nathan Chen, Dalton King, Jay Knipe, Lorraine Pajor, Astrid Ortiz, Valentin K Gribkoff, John Starrett

Bioorg Med Chem Lett. 2003 May 19;13(10):1695-8.

PMID: 12729644

Abstract:

A variety of water-soluble prodrugs of BMS-191011 was synthesized and evaluated for solution state stability and rate of conversion to BMS-191011 in rat and human plasma. The deoxycarnitine ester prodrug (11c) was selected for clinical evaluation based on its superior chemical stability, crystallinity and cleavage to BMS-191011 in human plasma.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP202821816 BMS-191011 BMS-191011 202821-81-6 Price
qrcode