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Synthetic Approaches to DNMT Inhibitor SGI-1027 and Effects on the U937 Leukemia Cell Line

Patricia García-Domínguez, Carmela Dell'aversana, Rosana Alvarez, Lucia Altucci, Angel R de Lera

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1631-5.

PMID: 23402879

Abstract:

The known DNMT inhibitor SGI-1027 4 has been synthesized using as key steps Pd-catalyzed Ar-N bond formation reactions performed in a sequential or convergent manner. In the former approach, a by-product, which corresponds to the incorporation of two units of 4-chloroquinoline, was also isolated. The biological effects of compound 4 in the U937 human leukemia cell line are also described.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1020149738 SGI-1027 SGI-1027 1020149-73-8 Price
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