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The COX-2 Inhibitor SC-236 Exerts Anti-Inflammatory Effects by Suppressing Phosphorylation of ERK in a Murine Model

The COX-2 Inhibitor SC-236 Exerts Anti-Inflammatory Effects by Suppressing Phosphorylation of ERK in a Murine Model

Su-Jin Kim, Hyun-Ja Jeong, Phil-Dong Moon, Noh-Yil Myung, Min-Cheol Kim, Tae-Hee Kang, Kang-Min Lee, Rae-Kil Park, Hong-seob So, Eun-Cheol Kim, Nyeon-Hyoung An, Jae-Young Um, Hyung-Min Kim, Seung-Heon Hong

Life Sci. 2007 Aug 23;81(11):863-72.

PMID: 17822719

Abstract:

SC-236, (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-]benzenesulfonamide; C(16)H(11)ClF(3)N(3)O(2)S) is a highly selective cyclooxygenase (COX)-2 inhibitor. Recently, there have been reports that SC-236 protects against cartilage damage in addition to reducing inflammation and pain for those with osteoarthritis. However, the mechanism involved in an inflammatory allergic reaction in a murine model has not been examined. The aim of the present study is to elucidate whether and how SC-236 modulates the inflammatory allergic reaction in a murine model. In this study, the anti-allergic effect was investigated using rat peritoneal mast cells, IgE-induced passive cutaneous anaphylaxis (PCA), and the ear-swelling model in mice. Also, we examined the inhibitory effect of SC-236 on the expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha. SC-236 was found to inhibit the ear-swelling response and histamine release in the murine model. Additionally, SC-236 was revealed to inhibit the PCA response and COX-2 expression. As a final step, the inhibitory mechanism of SC-236 was shown to occur through phosphorylation of extracellular signal-regulated protein kinase (ERK). These in vitro and in vivo results provide new insight into the pharmacological actions of SC-236 as a potential molecule for therapy for inflammatory allergic diseases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP170569865	SC-236		170569-86-5	Price

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