Home
Resources
Publications
The Diphenylpyrazole Compound anle138b Blocks Aβ Channels and Rescues Disease Phenotypes in a Mouse Model for Amyloid Pathology

The Diphenylpyrazole Compound anle138b Blocks Aβ Channels and Rescues Disease Phenotypes in a Mouse Model for Amyloid Pathology

Ana Martinez Hernandez, Hendrik Urbanke, Alan L Gillman, Joon Lee, Sergey Ryazanov, Hope Y Agbemenyah, Eva Benito, Gaurav Jain, Lalit Kaurani, Gayane Grigorian, Andrei Leonov, Nasrollah Rezaei-Ghaleh, Petra Wilken, etc.

EMBO Mol Med. 2018 Jan;10(1):32-47.

PMID: 29208638

Abstract:

Alzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Aβ pores without changing the membrane embedded Aβ-oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD-related pathology that should be investigated further.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP882697009	Anle138b		882697-00-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: