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The Identification of Potent and Selective Imidazole-Based Inhibitors of B-Raf Kinase

Andrew K Takle, Murray J B Brown, Susannah Davies, David K Dean, Gerraint Francis, Alessandra Gaiba, Alex W Hird, Frank D King, Peter J Lovell, Antoinette Naylor, Alastair D Reith, Jon G Steadman, David M Wilson

Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81.

PMID: 16260133

Abstract:

A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP405554554 SB-590885 SB-590885 405554-55-4 Price
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