0

The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling

Tommaso Cupido, Paul G Rack, Ari J Firestone, Joel M Hyman, Kyuho Han, Surajit Sinha, Cory A Ocasio, James K Chen

Angew Chem Int Ed Engl. 2009;48(13):2321-4.

PMID: 19222062

Abstract:

Eradicating hedgehogs: The title molecule has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This molecule is shown to modulate Hedgehog target gene expression by depolymerizing microtubules, thus revealing dual roles of the cytoskeleton in pathway regulation (see figure).

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP315703527 JK184 JK184 315703-52-7 Price
qrcode