Home
Resources
Publications
The Therapeutic Effect of Fraxetin on Ethanol-Induced Hepatic Fibrosis by Enhancing Ethanol Metabolism, Inhibiting Oxidative Stress and Modulating Inflammatory Mediators in Rats

The Therapeutic Effect of Fraxetin on Ethanol-Induced Hepatic Fibrosis by Enhancing Ethanol Metabolism, Inhibiting Oxidative Stress and Modulating Inflammatory Mediators in Rats

Xiaowei Chen, Xiaozhou Ying, Weiming Sun, Huijia Zhu, Xin Jiang, Bin Chen

Int Immunopharmacol. 2018 Mar;56:98-104.

PMID: 29414667

Abstract:

The present study was designed to investigate the possible protective effects of fraxetin against ethanol induced liver fibrosis in rats. Rats were underwent intragastric administration of ethanol (5.0-9.5 g/kg) once a day for 24 weeks. Effect of fraxetin against ethanol induced liver fibrosis was investigated by giving 20 or 50 mg/kg fraxetin. At the end of experiment, the livers were collected for histopathological analyses, protein extraction, and enzymatic activities. Our results indicated that fraxetin significantly corrected ethanol-induced hepatic fibrosis, as evidenced by the decrease in serum ALT and AST, the attenuation of histopathological changes. Fraxetin also expedited ethanol metabolism by enhancing the alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities. Besides, fraxetin alleviated lipid peroxidation, enhanced hepatic antioxidant capabilities, inhibited CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein. In summary, the hepatoprotection of fraxetin is mostly attributed to its antioxidant capability, alcohol metabolism, and anti-inflammation effect.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP574845	Fraxetin		574-84-5	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: