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Totally Synthetic Analogues of Siastatin B. III. Trifluoroacetamide Analogues Having Inhibitory Activity for Tumor Metastasis

Y Nishimura, T Kudo, S Kondo, T Takeuchi, T Tsuruoka, H Fukuyasu, S Shibahara

J Antibiot (Tokyo). 1994 Jan;47(1):101-7.

PMID: 8119851

Abstract:

A trifluoroacetamide analogue of siastatin B, (3S,4S,5R,6R)-6-(trifluoroacetamido)-4,5-dihydroxy-3-piperidine carboxylic acid has been chemically synthesized. This compound, as well as the previously synthesized analogue, (3R,4R,5R,6R)-6-(trifluoroacetamido)-3,4,5-trihydroxy-3-piperid inecarboxylic acid, showed marked inhibitory activity against beta-glucuronidase and significant inhibition of experimental pulmonary metastasis of the highly metastatic melanoma B16.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP54795583 Siastatin B Siastatin B 54795-58-3 Price
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