Custom Chromatographic Standards: Precision Solutions for Complex Analytical Needs

Reference standards play a critical role in modern analytical science by providing necessary accuracy, sensitivity, and reproducibility for chromatographic analyses. Appropriate standards selection and implementation throughout method development and validation phases ensures the experimental data remain reliable. As testing targets grow more complex and analytical techniques evolve, generic reference materials can no longer fulfill all analytical requirements. Thus, customized reference standards have become an emerging trend in high-end research and precision testing fields.

Leveraging a professional chemical synthesis and analytical platform and a deep understanding of chromatographic needs, our company offers high-quality customized chromatographic standards services to help clients achieve optimal solutions in complex testing systems.

Overview: Multi-Dimensional Customization to Match Your Analysis

We offer a wide range of standard customization services, from single-component standards to multi-component mixed standards, covering both routine solvent matrices and complex biological or environmental matrices. Our services include but are not limited to:

• Custom synthesis of single standards with specified structure, purity, or concentration
• Preparation of multi-component mixed standards with accurate composition and excellent stability
• Matrix-based standard customization in specific sample types (e.g., blood, urine, soil, water)

Each service can be tailored to the client's analytical needs, such as the analytical method, target compound properties, or applicable regulatory standards, thereby maximizing method development efficiency and reliability.

Core Offerings: Three Custom Solutions to Cover All Scenarios

1. Single Standard Customization

Single-component reference standards are critical in method development or when targeting a specific analyte. Based on structural information provided by the client (e.g., compound name, CAS number, SMILES, structural formula), we synthesize or prepare the target compound and control the following parameters as needed:

• Purity requirements: Standard purity levels are ≥95%, with options for ≥98%, ≥99.5%, or chromatographically pure levels based on HPLC
• Concentration customization: Prepared according to specified mass concentration (mg/mL), molarity (mol/L), or weight percentage (% w/w)
• Solvent compatibility: Recommended solvent systems (e.g., methanol, acetonitrile, DMSO, water) based on the analytical platform (GC, HPLC, LC-MS, etc.)

Additionally, antioxidants, buffering salts, or other stabilizing additives can be incorporated as required. All standards are accompanied by a Certificate of Analysis (COA), including HPLC chromatograms, NMR, MS, UV data, and are compliant with GLP or ISO-certified laboratory audit requirements.

2. Multi-Component Mixed Standards Customization

In multi-analyte detection scenarios—such as testing multiple additives in food, identifying diverse pollutants in environmental samples, or analyzing a range of drugs in biological fluids—mixed standards can greatly simplify experimental workflows and improve both data consistency and throughput.

We offer precise formulation of multi-component mixed standards based on client-specified component lists and concentration ratios, ensuring:

• Accurate and controllable concentrations for each component, ranging from ppb and ppm levels up to mg/mL
• No cross-reactivity or degradation between components, supported by stability and compatibility assessments
• Platform adaptability, such as avoiding m/z overlap or co-elution in LC-MS analysis

Mixed standards are ideal for the following applications:

• Pesticide and veterinary drug residue analysis
• Simultaneous detection of food additives (e.g., sweeteners, colorants, preservatives)
• Fingerprint profiling of traditional Chinese medicine ingredients
• Multi-impurity control in chemical product analysis

All mixed standards are subjected to stability testing before delivery. Recommended storage conditions and detailed composition (including ratios and solvent systems) are provided.

3. Matrix-Based Standards Customization

In many analytical tasks, matrix effects caused by the complexity of the sample matrix can significantly impact the behavior of reference standards. To better simulate actual testing conditions, we can dissolve or spike reference compounds directly into the required matrix, such as:

• Biological matrices: blood, plasma, urine, saliva, etc.
• Environmental matrices: surface water, wastewater, soil, sediment, etc.
• Food matrices: plant extracts, oils, beverages, fermentation products, etc.

This service supports more realistic testing in scenarios such as:

• Method validation and evaluation: including assessments of accuracy, matrix effects, and limits of detection (LOD)
• Blind sample quality control and analyst proficiency testing: to improve internal lab management
• Quantitative calibration in mass spectrometry using internal standards: better evaluation of recovery rates and ion suppression effects

All matrix-based standards are supplied with detailed preparation records and analytical verification reports to ensure product stability and traceability.

Why Choose Us: Four Key Strengths You Can Trust

Partnering with us for customized reference standards means choosing both professionalism and efficiency. Our key advantages include:

✅ Expert Scientific Team

Our team includes experts from diverse backgrounds such as organic synthesis, pharmaceutical analysis, and biological sample processing. They fully understand client needs and offer sound scientific recommendations.

✅ Strict Quality Control

All customized reference standards undergo a rigorous quality control process, with support for HPLC, GC, NMR, and LC-MS/MS analysis. Comprehensive COA documentation is provided for every batch.

✅ Flexible and Fast Turnaround

Typical delivery time is 5–10 working days for single-component standards and 10–15 working days for mixed or matrix-based standards, ensuring compatibility with tight project timelines.

✅ Broad Platform Compatibility

Our products are fully compatible with major analytical platforms, including gas chromatography (GC), high-performance liquid chromatography (HPLC), and tandem liquid chromatography–mass spectrometry (LC-MS/MS).

Real Applications: Industries We Serve and Success Stories

Our customized chromatographic standards are widely used across a range of industries and institutions, including:

• Pharmaceutical R&D and QC laboratories
• Food and agricultural product testing centers
• Environmental monitoring agencies and academic research labs
• Forensic science and clinical toxicology laboratories

Case Example:

A food testing institution needed to establish a high-throughput quantification method for 20 sweeteners. We provided a precisely formulated multi-component mixed standard and assisted in method validation using an LC-MS/MS platform. The project timeline was significantly shortened, and testing efficiency improved.

Let's Collaborate: Customized Standards to Elevate Your Research

Customized reference standards function as more than advanced laboratory analysis—they constitute necessary instruments for maintaining scientific precision and data reliability. Our advanced capabilities for customization together with our professional technical team and strict quality management system enable us to deliver stable and reliable standard solutions that meet compliance requirements.

Our expert team stands ready to assist you with your customized chromatographic standards requirements. Our products and services will help you achieve superior standards in scientific research and testing.