CAS 298-57-7 Cinnarizine - Analytical Products / Alfa Chemistry

CAT	APS298577
CAS	298-57-7
Structure
Synonyms	Marisan, Denapol, Hilactan, Corathiem, Stutgin, Glanil, Midronal, Carecin,Cinnarizine, 1-Cinnamyl-4-benzhydrylpiperazine, Cinaperazine, Dimitron, Sedatromin, Stutgeron, 1-Benzhydryl-4-cinnamylpiperazine, Stunarone, 516MD, Aplactan, Olamin, Cinnipirine, R 516, Mitronal, Cerebolan, Spaderizine, Dimitronal, Cinarizine, Apotomin, Cinnacet, 1-Diphenylmethyl-4-cinnamoylpiperazine, Piperazine, 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)- (9CI), Cinazyn, N-Benzhydryl-N'-cinnamylpiperazine, Stugeron, Eglen, Processine, Cerepar, Cinnarizine, Cinnageron, Vergo, 1-(3-Phenylallyl)-4-(diphenylmethyl)piperazine, 1-Cinnamyl-4-(diphenylmethyl)piperazine, Labyrin, Sepan, R 1575, (E)-1-(Diphenylmethyl)-4-(3-phenylprop-2-enyl)piperazine, Piperazine, 1-cinnamyl-4-(diphenylmethyl)- (6CI,7CI,8CI), Aplexal, Giganten, Siptazin, Artate, Katoseran, Folcodal, Ixterol, Lazeta, Toliman
IUPAC Name	1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine
Molecular Weight	368.51
Molecular Formula	C26H28N2
Canonical SMILES	C(\C=C\c1ccccc1)N2CCN(CC2)C(c3ccccc3)c4ccccc4
InChI	InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+

Accurate Mass	368.2252
Format	Neat
Type	API

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CAT	Size	Shipping	Storage Conditions	Description	Price
APS298577-1	100MG	Room Temperature	2-8°C Fridge/Coldroom	API Family: Matrix - API Family See respective official monograph(s); Subcategory: British Pharmacopoeia	Inquiry
APS298577-2	100MG	Room Temperature	2-8°C Fridge/Coldroom	API Family: Matrix - API Family See respective official monograph(s); Subcategory: European Pharmacopoeia (Ph. Eur.)	Inquiry
APS298577-3	250MG	Room Temperature	+5°C	API Family: Matrix - API Family Cinnarizine; Subcategory: Additional pharmaceutical toxicology reference materials, API standards, Mikromol	Inquiry

Case Study

Cinnarizine Used for the Preparation of HPLC Calibration Standards in Multi-Analyte Toxic Impurity Profiling

Edrees, Fadwa H., et al. RSC advances 11.3 (2021): 1450-1460.

Cinnarizine (CIN), an antihistaminic drug commonly co-formulated with Dimenhydrinate (DMH) for the treatment of vestibular disorders, was investigated in a newly developed HPLC method designed to simultaneously quantify active pharmaceutical ingredients alongside their toxic impurities. The study specifically targeted [1-(diphenylmethyl)piperazine] (DPP) and benzophenone (BZP), known degradants of CIN and DMH, respectively.
For analytical calibration and method validation, stock standard solutions of CIN, DMH, DPP, and BZP were prepared by dissolving 0.1 g of each compound in acetonitrile, yielding 1 mg/mL concentrations. Working solutions at 100 μg/mL were subsequently obtained via tenfold dilution using acetonitrile. These solutions served as the basis for constructing calibration curves essential for quantification.
A series of calibration standards with CIN concentrations ranging from 1 to 25 μg/mL were prepared by further dilution with mobile phase in 5 mL volumetric flasks. Injections of 30 μL were performed in triplicate for each concentration, and chromatographic analysis followed a custom-designed experimental approach to ensure optimal separation, peak symmetry, and minimal run time.
This study demonstrates the critical role of Cinnarizine in the preparation of reliable calibration standards, facilitating accurate, sensitive, and simultaneous HPLC analysis of pharmaceutical actives and their impurities-ensuring the safety and efficacy of fixed-dose formulations.

Cinnarizine Used for the Preparation of Calibration Solutions in UPLC Analysis of Fixed-Dose Formulations

Morgan, E. M., Lotfy, H. M., Obaydo, R. H., Fayez, Y. M., Abdelkawy, M., & Boltia, S. A. (2023). Sustainable Chemistry and Pharmacy, 36, 101225.

Cinnarizine, a key active pharmaceutical ingredient in fixed-dose combinations with Dimenhydrinate for vestibular disorders, was analyzed using two advanced UPLC systems to ensure quality and safety in dosage forms. Standard stock solutions of Cinnarizine (as well as Dimenhydrinate, and its toxic impurities 1-(diphenylmethyl)piperazine and benzophenone) were individually prepared in methanol at 1.0 mg/mL. Precise preparation of these solutions provided the foundation for robust calibration and quantification.
For UPLC-DAD analysis (System I), aliquots equivalent to 5.0-400.0 μg of Cinnarizine were accurately transferred from a 100 μg/mL working solution into 10-mL volumetric flasks, then diluted with methanol to achieve final concentrations of 0.5-40.0 μg/mL. Chromatographic conditions were optimized, and calibration curves were constructed by plotting relative peak areas versus concentration at 256.0 nm, with regression equations computed accordingly.
In UPLC-FLD (System II), aliquots corresponding to 1.0-60.0 μg of Cinnarizine were taken from a 10 μg/mL working solution and diluted to yield final concentrations of 0.1-6.0 μg/mL. Calibration here involved recording fluorescence emission using 251.0 nm as the excitation wavelength and appropriate emission wavelengths for Cinnarizine. This rigorous preparation and calibration process underscores Cinnarizine's pivotal role in achieving accurate, selective, and sensitive quantification in complex fixed-dose pharmaceutical matrices.

Cinnarizine Used for the Preparation of Calibration and Analytical Solutions in Binary Spectrophotometric Determination

Abdelrahman, Maha M. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 113 (2013): 291-296.

Cinnarizine, a calcium channel blocker frequently co-formulated with Domperidone for anti-vertigo therapy, was employed in the development of validated spectrophotometric methods for simultaneous determination in binary mixtures. These methods were specifically designed to resolve spectral overlap without prior separation, relying heavily on precise solution preparation.
To prepare the stock standard solution of Cinnarizine (1 mg/mL), 0.1 g of pure CIN was accurately weighed and transferred to a 100 mL volumetric flask. After dissolving in 50 mL methanol with gentle shaking, the volume was adjusted to the mark using methanol.
The working standard solution (100 μg/mL) was subsequently prepared by diluting 10 mL of the stock solution to 100 mL with methanol, ensuring consistency and stability for analytical use.
For spectral analysis, laboratory-prepared mixtures containing 40-180 μg of Cinnarizine were obtained by transferring precise aliquots of the working solution into 10 mL volumetric flasks. Corresponding volumes of Domperidone were added, and the mixtures were diluted with methanol and homogenized.
Absorption spectra of Cinnarizine (10 μg/mL) in methanol were recorded from 200-400 nm, with methanol as the blank. The careful preparation of these solutions enabled accurate, selective, and sensitive spectrophotometric quantification of Cinnarizine in complex pharmaceutical matrices.