CAS 20562-02-1 α-Solanine - Analytical Products / Alfa Chemistry

CAT	AP20562021
CAS	20562-02-1
Structure
MDL Number	MFCD00077873
Molecular Weight	868.06
EC Number	243-879-8
InChI Key	ZGVSETXHNHBTRK-UDJLNJFBSA-N
REAXYS Number	77607

Assay	≥95.0% (HPLC)
Size	10MG

Anti-Cancer Effect of α-Solanine by Down-Regulating S100P Expression in Colorectal Cancer Cells

Xiaofen Ni, Jiajun Chen, Fengying Lu, Zhengzhong Yuan, Xiaofeng Xu, Zhen Hu, Lei Jiang

Recent Pat Anticancer Drug Discov. 2018;13(2):240-247.

PMID: 29600769

Long Noncoding RNA GAS5 Modulates α-Solanine-induced Radiosensitivity by Negatively Regulating miR-18a in Human Prostate Cancer Cells

Jinhui Yang, Tongtong Hao, Jiantao Sun, Pengtao Wei, Han Zhang

Biomed Pharmacother. 2019 Apr;112:108656.

PMID: 30970507

α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167)

Ayşe Kübra Karaboğa Arslan, Mükerrem Betül Yerer

Nutrients. 2018 May 25;10(6):672.

PMID: 29799481

α-solanine Enhances the Chemosensitivity of Esophageal Cancer Cells by Inducing microRNA‑138 Expression

Jianbo Wu, Li Wang, Xinhui Du, Qianqian Sun, Yuanyuan Wang, Min Li, Wenqiao Zang, Kangdong Liu, Guoqiang Zhao

Oncol Rep. 2018 Mar;39(3):1163-1172.

PMID: 29328459

α-Solanine Impairs Oocyte Maturation and Quality by Inducing Autophagy and Apoptosis and Changing Histone Modifications in a Pig Model

Tao Lin, Reza K Oqani, Jae Eun Lee, Jeong Won Kang, So Yeon Kim, Eun Seok Cho, Yong Dae Jeong, Jun Jong Baek, Dong Il Jin

Reprod Toxicol. 2018 Jan;75:96-109.

PMID: 29247839

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Case Study

α-Solanine Induces Ferroptosis in Nasopharyngeal Carcinoma

Cui, Xuehui, et al. Journal of Functional Foods 104 (2023): 105517.

α-Solanine is a natural small molecule compound mainly derived from potato tubers, known for its antitumor and anti-inflammatory properties.
This study aimed to investigate whether α-solanine can induce nasopharyngeal carcinoma (NPC) cell death via ferroptosis and its underlying molecular mechanisms. Here, α-solanine was shown to induce ferroptosis in NPC cells by directly targeting HSP90α. The main features of α-solanine-induced ferroptosis in NPC HK-1 and 5-8F cells include elevated levels of ROS, MDA, iron, and mitochondrial structural changes. Additionally, SLC7A11 and GPX4 expression was significantly reduced. Mechanistic studies revealed that α-solanine binds directly to HSP90α, promoting p53 expression, which in turn suppresses SLC7A11 levels and leads to GPX4 inactivation. In summary, this study highlights the potential application of α-solanine in nasopharyngeal carcinoma treatment through ferroptosis.

α-Solanine Inhibits Cell Proliferation

Park, Sunwoo, et al. Chemosphere 235 (2019): 271-279.

α-Solanine is a toxic compound found in potatoes that exhibits cytotoxic effects on various cell types, including cancer cells. However, its impact on testicular function has not yet been determined. In this study, the antiproliferative effect of α-solanine in mouse testes was demonstrated for the first time.
α-Solanine disrupts mitochondrial membrane potential and accumulates cytosolic calcium ions in TM3 and TM4 cells. It increases the activation of AKT, P70S6K, S6, ERK1/2, and JNK proteins in TM3 and TM4 cells. Additionally, it inhibits cell proliferation by downregulating the mRNA expression of Ccnd1, Ccne1, Inha, and Inhba. In conclusion, α-solanine disrupts cell proliferation and function in mouse testes.

Protective and Therapeutic Effects of α-Solanine on Mouse Breast Cancer

Mohsenikia, M., Alizadeh, A. M., Khodayari, S., Khodayari, H., Karimi, A., Zamani, M., ... & Mohagheghi, M. A. (2013). European journal of pharmacology, 718(1-3), 1-9.

α-Solanine is a natural steroidal glycoalkaloid found in the leaves and fruits of plants, serving as a defense agent against fungi, bacteria, and insects. This study investigated the in vitro and in vivo toxicity of α-solanine and assessed its protective and therapeutic effects on a typical animal model of breast cancer.
α-Solanine appears to promote the opening of the mitochondrial permeability transition pore (mPTP) by reducing the membrane potential, leading to the release of Ca²⁺ from the mitochondria. This, in turn, results in an increased intracellular Ca²⁺ concentration, triggering Bax activation and Bcl-2 inhibition, ultimately resulting in apoptosis.