Terfenadine

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For research use only. Not intended for any clinical use
CATAP50679088
CAS50679-08-8
Structure: 
MDL NumberMFCD00079622
Molecular Weight471.67
EC Number256-710-8
InChI KeyGUGOEEXESWIERI-UHFFFAOYSA-N
Size5G, 25G
Solubilitychloroform: soluble 250 mg plus 5 ml of solvent, clear to very slightly hazy, colorless to faintly yellow; H2O: soluble 0.01 mg/mL at 30 °C; 1 M HCl: soluble 0.12 mg/mL at 30 °C; hexane: soluble 0.34 mg/mL at 30 °C; 0.1 M tartaric acid: soluble 0.45 mg/mL; 0.1 M citric acid: soluble 1.1 mg/mL; methanol: soluble 37.5 mg/mL at 30 °C; ethanol: soluble in salt form 37.8 mg/mL at 30 °C
Storage Conditions2-8°C

1Comparison of Electropharmacological Effects Between Terfenadine and Its Active Derivative Fexofenadine Using a Cross-Over Study in Halothane-Anesthetized Dogs to Analyze Variability of Pharmacodynamic and Pharmacokinetic Profiles of Terfenadine and Torsadogenic Risk of Fexofenadine

Kentaro Ando, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Hiroyuki Harada, Hiroyoshi Miyamoto, Naoki Inamura, Kan Takagi, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Hiroko Izumi-Nakaseko, Atsuhiko T Naito, Atsushi Sugiyama

J Toxicol Sci. 2018;43(3):183-192.

PMID: 29540652

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1Non-sedating antihistamines block G-protein-gated inwardly rectifying K + channels

I-Shan Chen, Chang Liu, Michihiro Tateyama, Izhar Karbat, Motonari Uesugi, Eitan Reuveny, Yoshihiro Kubo

Br J Pharmacol. 2019 Sep;176(17):3161-3179.

PMID: 31116876

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1On the Potential of in Vitro Organ-Chip Models to Define Temporal Pharmacokinetic-Pharmacodynamic Relationships

Christopher W McAleer, Amy Pointon, Christopher J Long, Rocky L Brighton, Benjamin D Wilkin, L Richard Bridges, Narasimham Narasimhan Sriram, Kristin Fabre, Robin McDougall, Victorine P Muse, Jerome T Mettetal, etc.

Sci Rep. 2019 Jul 3;9(1):9619.

PMID: 31270362

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1Second-Generation Histamine H1 Receptor Antagonists Suppress Delayed Rectifier K +-Channel Currents in Murine Thymocytes

Kazutomo Saito, Nozomu Abe, Hiroaki Toyama, Yutaka Ejima, Masanori Yamauchi, Hajime Mushiake, Itsuro Kazama

Biomed Res Int. 2019 Apr 30;2019:6261951.

PMID: 31183371

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1The exploration of effect of terfenadine on Ca 2 + signaling in renal tubular cells

He-Hsiung Cheng, Wei-Zhe Liang, Chun-Chi Kuo, Lyh-Jyh Hao, Chiang-Ting Chou, Chung-Ren Jan

J Recept Signal Transduct Res. 2019 Feb;39(1):73-79.

PMID: 31184240

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