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Reaction of Astaxanthin With Peroxynitrite

Reaction of Astaxanthin With Peroxynitrite

Tsutomu Hayakawa, Aditya Kulkarni, Yukimasa Terada, Takashi Maoka, Hideo Etoh

Biosci Biotechnol Biochem. 2008 Oct;72(10):2716-22.

PMID: 18838798

Abstract:

The in vitro reactivities of astaxanthin toward peroxynitrite were investigated and the reaction products after scavenging with peroxynitrite were analyzed in order to determine the complete mechanism of this reaction. A series of carotenoids, 13-apo-astaxanthinone (1), 12'-apo-15'-nitroastaxanthinal (2), 12'-apo-astaxanthinal (3), 10'-apo-astaxanthinal (4), 9-cis-14'-s-cis-15'-nitroastaxanthin (5), 14'-s-cis-15'-nitroastaxanthin (6), 13-cis-14'-s-cis-15'-nitroastaxanthin (7), 10'-s-cis-11'-cis-11'-nitroastaxanthin (8), 13,15,13'-tri-cis-15'-nitroastaxanthin (9), 9-cis-astaxanthin (10), and 13-cis-astaxanthin (11), were isolated from the reaction products of carotenoids with peroxynitrite. Our previous studies achieved for the first time the isolation of nitro derivatives from the reaction of astaxanthin with peroxynitrite. Here we identify the major remaining reaction products of this reaction and investigate the stabilities of the nitro astaxanthins.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP113085044	9-cis-Astaxanthin		113085-04-4	Price
AP113085055	13-cis-Astaxanthin		113085-05-5	Price

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