N-Propargyl Caffeamide: A Multifaceted Compound with Antioxidant, Anti-Inflammatory, and Neuroprotective Properties

Introduction of N-Propargyl Caffeamide

N-Propargyl Caffeamide (PACA) amide, a compound synthesized by Alfa Chemistry, has garnered significant attention in the scientific community due to its potential therapeutic properties. This compound belongs to the class of propargylamines and is a derivative of caffeic acid, a naturally occurring phenolic compound found in various plant sources. PACA is known for its antioxidant, anti-inflammatory, and neuroprotective effects, making it a promising candidate for the development of novel pharmaceutical agents.

Product List

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Catalog Number	Product Name	INQUIRY
AP1431724309	PACA	INQUIRY
APS1204669588	Epacadostat	INQUIRY
APS37270896	Heparin calcium for NMR identification	INQUIRY
APS37270896A	Nadroparin calcium	INQUIRY
APS489861	Guaiol	INQUIRY
APS489861A	Guaiol 100 µg/mL in Acetonitrile	INQUIRY
APS56776013	Tulobuterol hydrochloride	INQUIRY

Action Mechanism of N-Propargyl Caffeamide

The mechanism of action of PACA lies in its ability to modulate multiple signaling pathways within the body. Studies have shown that this compound exerts its antioxidant effects by scavenging free radicals and inhibiting oxidative stress-induced damage. Furthermore, PACA has been found to inhibit the activity of pro-inflammatory mediators, such as cytokines and chemokines, thus reducing inflammation in various tissues.

In addition to its antioxidant and anti-inflammatory properties, PACA has been shown to modulate neurotransmitter levels in the brain, particularly dopamine and serotonin. By enhancing the activity of these neurotransmitters, this compound may exert neuroprotective effects and improve cognitive function in individuals with neurodegenerative disorders.

Experimental Evidence of N-Propargyl Caffeamide

Numerous in vitro and in vivo studies have demonstrated the pharmacological potential of PACA. In a study, researchers investigated the neuroprotective effects of this compound in a mouse model of Parkinson's disease. They found that treatment with PACA significantly attenuated dopaminergic neuron loss and ameliorated motor deficits in the animals.

Applications in Scientific Research of N-Propargyl Caffeamide

PACA can be used as a research chemical in various studies and experiments. Some potential applications of this compound include:

Anti-cancer research: PACA has shown anti-cancer properties in some studies, making it a potential candidate for further research in cancer treatment.
Neuroprotection research: Studies have suggested that PACA may have neuroprotective effects, making it a promising compound for research on neurodegenerative diseases like Alzheimer's and Parkinson's.
Anti-inflammatory research: PACA has also been shown to have anti-inflammatory properties, which could make it a valuable compound for research on inflammatory conditions.
Drug discovery: Researchers may also use PACA as a starting point for the development of new drugs with improved efficacy and fewer side effects.

Furthermore, Alfa Chemistry has conducted its own research on the antioxidant properties of PACA, and our findings support the existing literature that PACA demonstrates strong antioxidant activity. This makes it a promising candidate for further research and development in the field of antioxidant therapy. Our team is dedicated to continuing to explore the potential benefits of PACA and its applications in various industries.

Reference

Cheng, Yuanyuan, et al. Cellular Physiology and Biochemistry 47.6 (2018): 2544-2557.

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